The efficacy of modafinil on EDS in individuals with MS was investigated in two large research. As revealed in Figure 3B, beneficial effect of modafinil on EDS was not confirmed during the pooled scientific tests. Similarly, the outcome of modafinil on EDS in TBI continues to be tested in two reports employing subjective measures. The study of Jha et al. with a larger variety of individuals didn’t verify the therapeutic effect of modafinil, whilst details from Kaiser et al. shown a transparent effective effect of modafinil on EDS.
Modafinil may very well be habit-forming. Never ever share modafinil with Yet another person, Specially an individual by using a background of drug abuse or habit. Keep the medication in a place where by Other folks are not able to reach it. Marketing or freely giving modafinil is towards the law.
A Exclusive MedGuide will probably be given to you personally through the pharmacist with Each and every prescription and refill. Make sure to look at this data meticulously every time.
Slight (1)modafinil will improve the degree or result of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Minimal/Importance Unidentified. Net impact on pantoprazole actions mysterious as a consequence of opposing effects of CYP450 enzymes; keep an eye on
If you believe there has been an overdose, contact your poison Management center or get medical treatment instantly. Be able to convey to or clearly show what was taken, the amount of, and when it occurred.
Liver ailment, extreme—Use with caution. You might website need a dose adjustment. Speak with your doctor Should you have concerns relating to this.
cannabidiol will boost the degree or result of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Intently. Take into consideration lowering the dose of delicate CYP2C19 substrates, as clinically proper, when coadministered with cannabidiol.
Stop getting this drugs and call your medical doctor instantly For those who have a pores and skin rash; itching; hives; hoarseness; problems respiration; hassle swallowing; or any swelling of the arms, face, or mouth while you're utilizing this medicine.
cannabidiol will improve the stage or influence of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Carefully. Look at lessening the dose of delicate CYP2C19 substrates, as clinically correct, when coadministered with cannabidiol.
phenytoin will lower the extent or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
B: Could possibly be appropriate. Both animal scientific tests demonstrate no risk but human studies not out there or animal experiments confirmed small hazards and human reports finished and confirmed no threat.
sparsentan will minimize the level or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and lessens efficacy connected with these substrates.
acetazolamide will enhance the amount or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
stiripentol will boost the level or outcome of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Intently. Take into consideration cutting down the dose of CYP2C19 substrates, if adverse reactions are seasoned when administered concomitantly with stiripentol.